Course Content
Course overview
A brief overview of the course purpose, instructors and purpose.
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Course Introduction
How to use this platform
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Abbreviation List
Resources & Guidelines
HIV Fundamentals (EPA N/A)
Build a solid foundation in HIV science (50 questions)
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Section notes
Fundamentals 1
Fundamentals 2
Fundamentals 3
Fundamentals 4
Fundamentals 5
HIV Prevention in Adults and Children (EPA 1.1)
Master HIV prevention strategies, counselling, and ethical issues with targeted questions and detailed explanations (50 questions)
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Section notes
HIV Prevention in Adults and Children 1
HIV Prevention in Adults and Children 2
HIV Prevention in Adults and Children 3
HIV Prevention in Adults and Children 4
HIV Prevention in Adults and Children 5
HIV in Adults and Adolescents (EPA 2.1 & 3.5)
Master HIV diagnosis and treatment in adults and adolescents (105 questions)
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Section notes
HIV in Adults and Adolescents 1
HIV in Adults and Adolescents 2
HIV in Adults and Adolescents 3
HIV in Adults and Adolescents 4
HIV in Adults and Adolescents 5
HIV in Adults and Adolescents 6
HIV in Adults and Adolescents 7
HIV in Children (EPA 3.1 & 3.3)
Master the essentials of paediatric HIV care from diagnosis to treatment failure management (90 questions)
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Section notes
HIV in Children 1
HIV in Children 2
HIV in Children 3
HIV in Children 4
HIV in Children 5
HIV in Children 6
Prevention of Vertical Transmission (EPA 4.1)
Learn to prevent vertical HIV transmission through quality maternal and neonatal care (60 questions)
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Section notes
Prevention of Vertical Transmission 1
Prevention of Vertical Transmission 2
Prevention of Vertical Transmission 3
Prevention of Vertical Transmission 4
Tuberculosis & HIV Co-infection in Adults (EPA 5.1)
Diagnose and manage TB in adults with HIV, including extrapulmonary and drug-resistant forms (60 questions)
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Section notes
Tuberculosis & HIV Co-infection in Adults 1
Tuberculosis & HIV Co-infection in Adults 2
Tuberculosis & HIV Co-infection in Adults 3
Tuberculosis & HIV Co-infection in Adults 4
Tuberculosis & HIV Co-infection in Children (EPA 3.3 & 3.4)
Understand TB care in HIV-positive children with emphasis on child-specific approaches (60 questions)
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Section notes
Tuberculosis & HIV Co-infection in Children 1
Tuberculosis & HIV Co-infection in Children 2
Tuberculosis & HIV Co-infection in Children 3
Tuberculosis & HIV Co-infection in Children 4
HIV and Sexual/ Reproductive Health (EPA 4.2)
Integrate sexual health, contraception, and STI management into HIV care (50 questions)
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Section notes
HIV and Sexual/ Reproductive Health 1
HIV and Sexual/ Reproductive Health 2
HIV and Sexual/ Reproductive Health 3
HIV and Sexual/ Reproductive Health 4
HIV and Sexual/ Reproductive Health 5
HIV and the Nervous System (EPA 5.2, 5.9)
Recognise and manage neurological complications in people living with HIV (55 questions)
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Section notes
HIV and the Nervous System 1
HIV and the Nervous System 2
HIV and the Nervous System 3
HIV and the Nervous System 4
HIV and the Nervous System 5
HIV and the Gastrointestinal Tract (EPA 5.3, 5.5 & 6.1)
Manage gastrointestinal and liver conditions in HIV, including ART implications (50 questions)
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Section notes
HIV and the Gastrointestinal Tract 1
HIV and the Gastrointestinal Tract 2
HIV and the Gastrointestinal Tract 3
HIV and the Gastrointestinal Tract 4
HIV and the Gastrointestinal Tract 5
HIV and the Respiratory System (EPA: 3.3 & 5.4)
Approach HIV-associated respiratory illness with integrated diagnostic and treatment strategies (45 questions)
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Section notes
HIV and the Respiratory System 1
HIV and the Respiratory System 2
HIV and the Respiratory System 3
HIV and the Respiratory System 4
Dermatologic & Mucocutaneous Conditions in HIV (EPA 5.5 & 5.6)
Identify and manage HIV-related skin conditions and drug reactions (40 questions)
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Section notes
Dermatologic & Mucocutaneous Conditions in HIV 1
Dermatologic & Mucocutaneous Conditions in HIV 2
Dermatologic & Mucocutaneous Conditions in HIV 3
Dermatologic & Mucocutaneous Conditions in HIV 4
Mental Health and HIV (EPA 5.7)
Address mental health in HIV care with screening and integrated support (45 questions)
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Section notes
Mental Health and HIV 1
Mental Health and HIV 2
Mental Health and HIV 3
Mental Health and HIV 4
Malignancies in HIV (EPA 5.8)
Manage HIV-associated cancers with a focus on early identification and integrated care (25 questions)
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Section Notes
Malignancies in HIV 1
Malignancies in HIV 2
HIV and Haematology (EPA 6.2)
Recognise and manage haematological complications of HIV and its treatment (25 questions)
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Section Notes
HIV and Haematology 1
HIV and Haematology 2
HIV and Co-morbidities (EPA 6.1, 6.3, 6.5, 7.1)
Coordinate HIV care in patients with chronic comorbidities (50 questions)
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Section notes
HIV & Co-morbidities 1
HIV & Co-morbidities 2
HIV & Co-morbidities 3
HIV & Co-morbidities 4
HIV & Co-morbidities 5
Treatment Failure in Adults and Children (EPA 2.2, 3.2)
Gain confidence in identifying and managing ART failure in adults and children (50 questions)
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Section Notes
Treatment Failure 1
Treatment Failure 2
Treatment Failure 3
Treatment Failure 4
Treatment Failure 5
Advanced HIV Disease (EPA N/A)
Build your knowledge in managing advanced HIV illness across multiple domains (55 questions)
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Section Notes
Advanced HIV Disease 1
Advanced HIV Disease 2
Advanced HIV Disease 3
Advanced HIV Disease 4
Advanced HIV Disease 5
Advanced HIV Disease 6
Antiretroviral Drugs (6.4)
Build confidence in understanding ART through clinical cases covering drug classes, side effects, and interactions (60 questions)
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Section notes
ART 1
ART 2
ART 3
ART 4
ART 5
ART 6
Adherence, Retention in Care & Key Populations (EPA 8.1)
Strengthen your approach to HIV adherence and retention with tailored strategies for diverse populations (35 questions)
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Section notes
Adherence 1
Adherence 2
Adherence 3
Course Completion & Next Steps
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Course Completion & Next Steps
HIV Diploma Review & Practice Course
About Lesson

Resources and Guidelines

This course content was developed using a range of guidelines and resources. Candidates are strongly encouraged to review these documents, as the multiple choice questions are based on the latest national clinical protocols and evidence-based recommendations.

Adult and Child HIV & ART Guidelines

  1. National Department of Health (South Africa). National Consolidated Guidelines for the Management of HIV in Adults, Adolescents, Children, and Infants. 2023.
  2. National Department of Health (South Africa). Guidelines for the Prevention of Vertical Transmission of HIV. 2023.
  3. Southern African HIV Clinicians Society (SAHCS). Adult Advanced HIV Disease (AHD) Guideline. 2022.
  4. National Department of Health (South Africa). South African Antiretroviral Therapy Clinical Guidelines. 2022.
  5. National Department of Health (South Africa). Paediatric and Adolescent HIV Treatment Guidelines. 2022.
  6. Southern African HIV Clinicians Society (SAHCS). Dolutegravir Interactions Information Sheet.
  7. Southern African HIV Clinicians Society (SAHCS). Guideline for Post-Exposure Prophylaxis: Updated Recommendations. 2023.
  8. Southern African HIV Clinicians Society (SAHCS). Pre-exposure Prophylaxis (PrEP) FAQ. 2021.
  9. National Department of Health (South Africa). National HIV Testing Services Policy. 2016.
  10. National Department of Health (South Africa). Differentiated Models of Care: Standard Operating Procedures. 2023.
  11. National Department of Health (South Africa). Adult Primary Care: Symptom-Based Integrated Care for Adults in South Africa. Pretoria: NDoH; 2023.

Tuberculosis Guidelines

  1. National Department of Health (South Africa). Childhood Tuberculosis Guidelines. 2024.
  2. National Department of Health (South Africa). National Guidelines on the Treatment of Tuberculosis Infection. 2023.
  3. National Department of Health (South Africa). Clinical Management of Rifampicin-Resistant Tuberculosis. 2023.
  4. National Department of Health (South Africa). National TB Management Guidelines. 2014.
  5. World Health Organization (WHO). Consolidated Guidelines on HIV and TB – Selected sections used where aligned with national policy.
  6. National Department of Health (South Africa). Circular on Revised Guidance for TB Preventive Therapy (TPT) in Pregnancy. 30 January 2025.
  7. Meintjes G, Maartens G. Management of drug-induced liver injury in HIV-positive patients treated for TB. Southern African Journal of HIV Medicine. 2013;14(3):113–119. DOI: 10.7196/SAJHIVMED.995
  8. National Department of Health (South Africa). Management of Suspected Drug-Induced Rash, Kidney Injury and Liver Injury in Adult Patients on TB Treatment: Clinical Guidance. Pretoria: NDoH; July 2020.

Co-morbidities and Opportunistic Infections

  1. National Department of Health (South Africa). Standard Treatment Guidelines and Essential Medicines List – Hospital Level (Adults and Paediatrics). 2023.
  2. National Department of Health (South Africa). Adult Primary Care: Symptom-Based Integrated Care for Adults in South Africa. Pretoria: NDoH; 2023.
  3. Southern African HIV Clinicians Society (SAHCS). South African Cryptococcal Meningitis Guideline. 2023.
  4. National Department of Health (South Africa). South African Hepatitis B Guideline. 2023.
  5. Southern African HIV Clinicians Society (SAHCS). Guideline for the Prevention, Diagnosis and Management of Cryptococcal Disease among HIV-Infected Persons: 2019 Update.
  6. Southern African HIV Clinicians Society (SAHCS). Guidelines for the Management of Mental Health Disorders and CNS Sequelae in HIV-Positive Children and Adolescents. 2014.
  7. Uthman OA, Magidson JF, Safren SA, et al. Depression and adherence to antiretroviral therapy in low-, middle- and high-income countries: a systematic review and meta-analysis. Curr HIV/AIDS Rep. 2014.

Sexual and Reproductive Health

  1. Southern African HIV Clinicians Society (SAHCS). Guidelines for the Management of Sexually Transmitted Infections. Johannesburg: SAHCS; 2022.
  2. National Department of Health (South Africa). Cervical Cancer Prevention and Control Policy. Pretoria: NDoH; 2017.
  3. National Department of Health (South Africa). South African Syphilis Guideline. 2023.
  4. Southern African HIV Clinicians Society (SAHCS). Guideline on the Management of HIV-Serodiscordant Couples. Southern African Journal of HIV Medicine. 2015;16(1):Art.#367. DOI: 10.4102/sajhivmed.v16i1.367

Childhood HIV & Related Diseases

  1. Integrated Management of Childhood Illness (South Africa). IMCI Chart Booklet. 2022.
  2. National Department of Health (South Africa). Standard Treatment Guidelines and Essential Medicines List – Hospital Level (Adults and Paediatrics). 2023.
  3. Southern African HIV Clinicians Society (SAHCS). Guidelines for Adherence to Antiretroviral Therapy in Adolescents and Young Adults.
  4. National Department of Health (South Africa). Disclosure Guidelines for Children and Adolescents in the Context of HIV, TB and Non-Communicable Diseases. 2016.
  5. Southern African HIV Clinicians Society (SAHCS). Guidelines for the Management of Mental Health Disorders and CNS Sequelae in HIV-Positive Children and Adolescents. 2014.
  6. National Department of Health (South Africa). Expanded Programme on Immunisation in South Africa (EPI-SA): Vaccination Guidelines. 2023.
  7. National Department of Health (South Africa). Paediatric Dolutegravir 10mg Dispersible, Scored Tablets: Information for Healthcare Workers.

Malignancies

  1. National Department of Health (South Africa). Standard Treatment Guidelines and Essential Medicines List for Hospital Level Adults. 2023 Edition. Pretoria: NDoH; 2023.
  2. Yarchoan R, Uldrick TS. HIV-associated cancers and related diseases. New England Journal of Medicine. 2018;378(11):1029–1041. DOI: 10.1056/NEJMra1615896

These references ensure the course remains up to date, locally relevant, and aligned with the CMSA Diploma in HIV Management examination.

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